Over the past decade, substantial progress has been made in defining strategies for the treatment of human immunodeficiency virus (HIV) disease, the cause of acquired immunodeficiency syndrome (AIDS) , where natural products can serve as a source of structurally novel chemicals that are worth investigating as specific inhibitors of HIV as well as its essential enzymes, protease (PR) and reverse transcriptase (RT).
Ganoderma lucidum is one of the valuable crude drugs, which has long been used in China and Japan as a traditional Chinese medicine or a folk medicine for the treatment of various kinds of diseases. Several biologically active triterpenes and sterols have been isolated from this mushroom and proved effective as cytotoxic, antiviral and anti-inflammatory agents. Besides, polysaccharides and glycoproteins possessing hypoglycemic and immunostimulant activities have also been isolated from its water extract. In the course of our continuing search for natural products as anti-HIV agents, the MEOH extract of the fruiting bodies was found to be moderately active against HIV-1 as well as its essential enzyme, protease (PR). Therefore this extract was selected for further fractionation. When subjected to bioassay-guided fractionation, the extract yielded several active compounds. This paper describes the isolation of thirteen compounds, and their inhibitory effects against HIV-1 and its enzyme PR.
Preliminary clinical reports and practitioner experience seems to indicate that its immunostimulating polysaccharides may make it useful for people who are HIV positive, as well as for those who have Epstein Barr Virus (EBV), an infectious virus that causes mononucleosis (Dharmandanda,1988).
Ganoderma lucidum is one of the valuable crude drugs, which has long been used in China and Japan as a traditional Chinese medicine or a folk medicine for the treatment of various kinds of diseases. Several biologically active triterpenes and sterols have been isolated from this mushroom and proved effective as cytotoxic, antiviral and anti-inflammatory agents. Besides, polysaccharides and glycoproteins possessing hypoglycemic and immunostimulant activities have also been isolated from its water extract. In the course of our continuing search for natural products as anti-HIV agents, the MEOH extract of the fruiting bodies was found to be moderately active against HIV-1 as well as its essential enzyme, protease (PR). Therefore this extract was selected for further fractionation. When subjected to bioassay-guided fractionation, the extract yielded several active compounds. This paper describes the isolation of thirteen compounds, and their inhibitory effects against HIV-1 and its enzyme PR.
Preliminary clinical reports and practitioner experience seems to indicate that its immunostimulating polysaccharides may make it useful for people who are HIV positive, as well as for those who have Epstein Barr Virus (EBV), an infectious virus that causes mononucleosis (Dharmandanda,1988).
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